Abstract：The inetermediate, 4-methylamino-6-trifluoromethyl-2-(methylthio)pyrimidine（3）, was prepared by cyclization, chlorination and nucleophilic substitution reaction， using ethyl trifluoroacetate and thiourea as starting materials. The novel compound, 4-methylamino-6-trifluoromethyl-2-(methylsulfonyl)pyrimidine（4）， was synthesized by oxidation of 3 using m-CPBA as the oxidant. The structure was characterized by 1H NMR, MS, elemental analysis and X-ray single crystal diffraction. 4 (CCDC: 973 037) belongs to monoclinic system, P2(1)/c，晶胞参数a=5.068 7(4) , b=15.296 8(11) , c=13.833 9(10) , β=13.833 9(10)°， V=1 065.81(14) 3, Z=4, Dc＝1.591 g·cm-3, μ=0.336 mm-1, F(000)=520， R1=0.051 1, wR2=0.135 3。
黄统辉， 孙杰， 王倩倩， 张力弦， 涂海洋. 4-甲胺基-6-三氟甲基-2-甲砜基嘧啶的合成及其晶体结构[J]. 合成化学, 2015, 23(10): 941-944.
HUANG Tong-hui, SUN Jie, WANG Qian-qian, ZHANG Li-xian, TU Hai-yang. Synthesis and Crystal Structure of 4-Methylamino-6-trifluoromethyl-2-(methylsulfonyl)pyrimidine. Chinese Journal of Synthetic Chemistry, 2015, 23(10): 941-944.
2015, Vol. 23 
