Facile Synthesis of (3, 3-Difluorcyclohexyl)Methanmine
ZHAO Yu-ling, QIU Ji-kuan
Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China
Abstract：(3,3-Difluorcyclohexyl)methanmine（4） in total yield of 55% was synthesized by Michael addition reaction, hydrolyzation decarboxylation, nucleophilic fluorination and reduction reaction， usingcyclohex-2-en-1-one and ethyl nitroacetate as raw materials. The structure was confirmed by 1H NMR and MS. Under the optimal reaction conditions［1，1-difluoro-3-(nitromethyl)cyclohexane 83.73 mmol, Raney Ni(80％)+NH3·H2O as the co-catalyst, EtOH as the solvent, at room temperature for 12 h］, the yield of 4 was 82%.
2015, Vol. 23 
