Synthesis and Anti-inflammatory Activities of Oxazolone Compounds
SUN Yin-xing1, XU Guang-lin2, HOU Bing-bo1, AO Gui-zhen1
1. Faculty of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China; 2. New Drug Research Center of Faculty of Life Science, Nanjing Normal University, Nanjing 210046, China
Abstract：Eight oxazolone compounds(3a~3h) were synthesized by Erlenmeyer cyclization of hippuric acid with substituted benzaldehyde. The structures were confirmed by 1H NMR, FT-IR and HR-MS. The results of anti-inflammation by xyleneinduced mice ear edema suggested that 3f［4-（3,5-dimethoxy-benzylidene)-2-phenyl-4H-5-oxazolone］ exhibited better anti-inflammatory activity(50.3%) than aspirin(41.5%).
2015, Vol. 23 
