Synthesis of Novel Potassium(3-fluoro-2-amino-substituted pyridin-4-yltrifluoroborates)
TENG Ming-gang1, ZHAO Chun-shen2, DUAN Lian1, CHAI Hui-fang1
1. Department of Pharmacy, Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China; 2. School of Pharmacy, Guizhou University, Guiyang 550025, China
Abstract：2-Substituted-amino-3-fluoropyridine compounds(2a~2g) were synthesized by substitution and reduction from 2,3-difluoro-5-chloropyridine. A series of pyridine boric acid compounds(3a~3g)were obtained by reaction of 2 with n-butyllithium and triisopropyl borate. Finally， seven novel potassium(3-fluoro-2-amino substituted pyridin-4-yltrifluoroborates) were synthesized by substitution of 3a~3g with potassium hydrogen fluoride， respectively． The structures were characterized by 1H NMR, 13C NMR, IR, ESI-MS and elemental analysis.
2016, Vol. 24 
