Synthesis and Cytotoxicity of A Novel O6-benzylguanine Derivative
LI Si-si1, PENG Rui-zeng2
1. Institute of Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China; 2. College of Life Science & Bioengineering, Beijing University of Technology, Beijing 100124, China
Abstract：A novel O6-benzylguanine(O6-BG) derivative, 4-nitrobenzyl-［6-(benzyloxy)-9H-purin-2-yl］carbamate(4), was synthesized by a four-step reaction, using O6-BG as starting material. The structure was characterized by 1H NMR and HR-ESI-MS. The cytotoxicities of 4 were investigated by CCK-8 method. The results indicated that 4 exhibited better inhibition activities against human glioma cell lines(SF126, SF763 and SF767) with ACUN than O6-BG under hypoxia conditions. IC50 of 4 against SF126, SF763 and SF767 were 0.04 mM, 0.1 mM and 0.03 mM, respectively.
李思思， 彭瑞增. 新型O6-苄基鸟嘌呤衍生物的合成及其细胞毒性[J]. 合成化学, 2016, 24(2): 160-163.
LI Si-si, PENG Rui-zeng. Synthesis and Cytotoxicity of A Novel O6-benzylguanine Derivative. Chinese Journal of Synthetic Chemistry, 2016, 24(2): 160-163.
2016, Vol. 24 
