Abstract：Stigmasterol(1) was separated from phytosterol. The intermediate, 3-ketobisnor-4-cholenaldehyde(3) was prepared through oppenauer oxidation and ozonation from 1. Progesterone was synthesized by addition-condensation and oxygenation catalyzed by cuprous chloride from 3. The overall yield was 69.1%. The structure was confirmed by 1H NMR and ESI-MS.
吴庆安, 徐志超, 柏挺. 黄体酮的合成工艺改进[J]. 合成化学, 2016, 24(2): 174-177.
WU Qing-an, XU Zhi-chao, BAI Ting. Process Improvement on the Synthesis of Progesterone. Chinese Journal of Synthetic Chemistry, 2016, 24(2): 174-177.