Synthesis of N-(2-chloroethyl)-N′-2-(O6-benzyl-9-guanineyl)ethyl-N-nitrosourea" />
<em>N</em>-(2-氯乙基)-N′-2-(<em>O<sup>6</sup></em>-苄基-9-鸟嘌呤基)乙基-N-亚硝基脲的合成
Synthesis of N-(2-chloroethyl)-N′-2-(O6-benzyl-9-guanineyl)ethyl-N-nitrosourea
WANG Ya-meng, REN Ting, SONG Xiu-qing, ZHAO Li-jiao, ZHONG Ru-gang
Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China
Abstract：N-9-(2-amino)ethyl-O6-benzylguanine(4) was obtained through substitution and Gabriel reaction, using O6-benzylguanine as the starting material. N-(2chloroethyl)-N′-2-(O6-benzyl-9-guanine)ethyl-N-nitrosourea(6) was synthesized by isocyanate substitution of 4, followed by a nitrosation reaction. 4 and 6 were new compounds. And their structures were characterized by UV- Vis, 1H NMR, 13C NMR, IR and HR-ESI-MS.
2016, Vol. 24 
