Abstract：A new one-pot synthetic method to prepare multiple fluorine substituted biaryl compounds(3a~3f) by diazotization/cross-coupling of aromatic anilines with poly-uoroarenes had been developed. The yields were 56%~82%. The structures were confirmed by 1H NMR, 19F NMR and EI-MS．Under the optimized conditions［1a 2 mmol, 20%CuI as the catalyst，150%Bu4NI as the iodide reagent， V(DMSO）: V （MeCN）=1 : 1 as the solvent， at 130 ℃ for 4 h］, the yield of 3a was 75%.
计燕萍， 杨芸， 高广春. 一种合成多氟联苯类化合物的新方法[J]. 合成化学, 2016, 24(3): 259-262.
JI Yan-ping, YANG Yun, GAO Guang-chun. A New Method for Synthesis of Multiple Fluorine Substituted Biaryl Compounds. Chinese Journal of Synthetic Chemistry, 2016, 24(3): 259-262.
2016, Vol. 24 
