Synthesis, Characterization and Anticancer Activity of Cis-oxalate-dimycophenolic Acid-(trans-1,2-cyclohexanediamine)platinum(Ⅳ)
LIU Qixing1*, WANG Yingfei1, XIE Lijiao1, CONG Yanwei1, ZENG Yan1, SUN Mingneng1, SHEN Qingfei2
1. Kunming Guiyan Pharmaceutical Co., Ltd., Kunming 650106, China; 2. College of Vocational and Technical Education, Yunnan Normal University, Kunming 650500, China
Abstract：A new platinum(Ⅳ) complex, cis-oxalate-dimycophenolic acid-(trans-1,2-cyclohexanediamine)platinum(Ⅳ), was designed and synthesized. The structure was characterized by elemental analysis (EA), mass spectrometry (MS), Fourier transform infrared spectrometry (FT-IR) and nuclear magnetic resonance (NMR). The antitumor activity of the target compound was evaluated by methyl thiazolyl (MTT) method. The results showed that the structure of the compound was consistent with the expected assumption, and it had obvious inhibitory activity on the growth of 4 common cancer cells (SW480, HCT-116, A2780 and U-2OS). With the highest concentration of administration, the inhibition rates were 37.43%, 71.56%, 33.27% and 65.23% respectively.
