A New Synthetic Method of α-Sulfo-β-amino Acid Esters
HU Xiao-yan1,2, HU Fang-zhi1,2, YUAN Wei-cheng1, ZHANG Xiao-mei1
1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China; 2. University of Chinese Academy of Sciences, Beijing 100049, China
Abstract：Five novel α-sulfo-β-enamioesters(3a~3e) were synthesized by oxidative coupling reaction of β-enamioesters and N-(thio)succinimide, using CuBr2 as the catalyst. Then they were hydrosilylated to afford five α-sulfo-β-amino acid moieties(4a~4e). The structures were characterized by 1H NMR. Under the optimized reaction conditions(3 0.1 mmol， HSiCl3 2.0 eq., DCE 1 mL， at room temperature for 12 h), the yield of 4a was 97%.
扈晓艳, 胡方芝, 袁伟成, 张晓梅. 一种合成α-硫代-β-氨基酸酯的新方法[J]. 合成化学, 2016, 24(4): 326-329.
HU Xiao-yan, HU Fang-zhi, YUAN Wei-cheng, ZHANG Xiao-mei. A New Synthetic Method of α-Sulfo-β-amino Acid Esters. Chinese Journal of Synthetic Chemistry, 2016, 24(4): 326-329.
2016, Vol. 24 
