Abstract：Pyrazines are important heterocyclic compounds, widely used in medicine, organic synthesis and coordination chemistry. Herein, a facile and efficient method for the synthesis of pyrazines is described, where [RuCl2(p-cymene)]2/KOAc catalyzed dehydrogenation of dihydropyrazines to afford various pyrazine derivatives 2a~2p in 43%~90% isolated yields. All of the compounds were confirmed as target compounds by 1H NMR, 13C NMR, IR and elemental analysis.
洪建权，马明玉，曹华鹏，富莹莹，冯瑞龙，赵奎，郑昌戈. 钌催化二氢吡嗪脱氢：一种简便合成吡嗪的方法[J]. 合成化学, 2023, 31(3): 216-221.
HONG Jianquan, MA Mingyu, CAO Huapeng, FU Yingying, FENG Ruilong, ZHAO Kui, ZHENG Changge. Ruthenium-catalyzed Dehydrogenation of Dihydropyrazines: A Facile Approach to Synthesis Pyrazines. Chinese Journal of Synthetic Chemistry, 2023, 31(3): 216-221.
