1. 四川农业大学 a. 理学院（四川 雅安 625014）； b. 农学院； c. 动物医学院，四川 成都 611130
Synthesis of 3-Substituted 3-phenyl-1-indanone Compounds
WANG Ze-yu1a, DING Gang1a,1b, YIN Zhong-qiong1c, YUE Gui-zhou1a,1b
a. College of Science(Ya’an 625014); b. College of Agricultural Science; c. College of Veterinary Medicine, 1. Sichuan Agricultural University， Chengdu 611130, China
Abstract：Four 3-substituted-3-phenyl-1-indanone compounds（3a~3d, 3b~3d were novel compounds） were synthesized by nucleophilic substitution reaction of 3-phenyl-1-indanone（1） with iodides（RI）， using LDA as base and THF as solvent. The structures were characterized by 1H NMR， 13C NMR and EI-GC-MS． The yield of 3a~3d were 70％～80％ under the optimum reaction conditions（1 1.0 eq., LDA/RI=2.1/1.5, at 0 ℃~rt for 5 h）.
2015, Vol. 23 
