State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Bioengineering of Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, China
Abstract：Fifteen novel 1,3,4-thiadiazole amide compounds containing piperazine were synthesized using aminothiourea and carbon disulfide as the starting materials. The structures were characterized by 1H NMR，13C NMR，IR, ESI-MS and elemental analysis. The bioassay results indicated that N-｛5-［(2,4-dichlorobenzyl)thio]-1,3,4thiadiazol-2-yl｝-2-(4-methylpiperazin-1-yl)acetamide(6b) and N-【5-｛［4-(trifluoromethoxy)benzyl］thio｝-1,3,4-thiadiazol-2-yl】-2-(4-methylpiperazin-1-yl)acetamide(6e) demonstrated inhibitory effects on Xan-thomonas campestris pv.oryzae with EC50of 17.5 μg·mL-1 and 19.8 μg·mL-1, respectively. N-｛5-［(3-methylbenzyl)thio]-1,3,4-thiadiazol-2-yl｝-2-(piperazin-1-yl)acetamide(6k) showed certain antiviral activity against tobacco mosaic virus at 500 μg·mL-1.
2015, Vol. 23 
