Myrtenic acid(3) was prepared by oxidation of α-pinene. Aliphatic bis-thiadiazoles（4a~4h） were prepared by reaction of aliphatic dicarboxylic acids with thiosemicarbazide in the presence of POCl₃. Eight novel myrtenal-based bisamide-thiadiazole compounds（5a~5h） were synthesized by condensation of 4a~4h with 3, respectively. The structures were characterized by ¹H NMR， ¹³C NMR， IR and ESI-MS. Antifungal activities test showed that 5a~5h exhibited certain antifungal activities against Fusarium oxysporum f.cucumerinum, Cercospora arachidicola, Physalospora piricola, Alternaria solani and Fusarium graminearumat 50 μg·mL^-1. Myrtenal-suberic acid-based bisamide-thiadiazole(5f) had inhibition rate of 60.3% against Physalospora piricola, myrtenal-amber acid-based bisamide-thiadiazole(5b) and myrtenal-sebacic acid-based bisamide-thiadiazole(5h) had inhibition rates of 52.8% and 54.4% against Fusarium graminearum, respectively.