Abstract:Sixteen novel 1H-[1,2,3]triazole[4,5-c]pyridazine compounds were synthesized from aromatic amine, iodomethane, tert-butyl 4-[(methylsulfonyl)oxy]piperidine-1-carboxylate and 2-(2-bromoethoxy)tetrahydro-2H-pyran by substitution, oxidization and Suzuki reaction, using 3,4,6-trichloropyridazine and 4-iodo-1H-pyrazole as starting materials. The structures were characterized by 1H NMR and ESI-MS.