Synthesis of 17α,21-Dihydroxypregn-4-ene-3,20-dione-17-valerate
WU Qing-an1,2, WU Hong-wei1, BAI Ting2
1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China;2. Shanghai New Hualian Pharmaceutical Company Limited, Shanghai 201400, China
Abstract：The intermediate of hydrocortisone, 17α,21-dihydroxypregn-4-ene-3,20-dione-17-valerate, was synthesized by a seven-step reaction of addition, silicon etherification, cycloaddition-protiodesilylation and so on, using androstendione as the starting material. The total yield was about 75% and purity was more than 96%. The structure was confirmed by 1H NMR and ESI-MS.
2016, Vol. 24 
