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| Synthesis of Dihydropyrimidin 2(1H) ones by Aqueous Biginelli Reaction under Ultrasonic Irradiation |
| WANG Ying, JIAO Rui |
| Department of Chemistry, Lianyungang Teachers College, Lianyungang 222006, China |
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Abstract Eleven 3,4-dihydropyrimidin-2(1H) ones were efficiently synthesized by aqueous Biginelli reaction of β-ketoester, aldehyde and urea(or thiourea) catalyzed by NaHSO4 under ultrasonic irradiation with the yields of 80%~93%. The structures were confirmed by 1H NMR and HR-MS.
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Received: 30 June 2015
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2015, Vol. 23 
