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| Synthesis and Anticancer Activities of Novel Oxovanadium(IV) Complexes［VO(dtbsal-met)(phen) and VO(naph-met)(phen)］ |
| CAO Ya-ping, YI Cen-lan, LIU Hong-mei,LI Hai-xia, ZUO Jian-li, YUAN Ze-li |
| School of Pharmacy, Zunyi Medical University, Zunyi 563003, China |
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Abstract Two novel oxovanadium(IV) complexes， VO(dtbsal-met)(phen)（1） and VO(naph-met)(phen)（2）, were synthesized by aldimine condensation reaction reaction, using L-methionine(meth), 1,10-phenanthroline(phen)， 3,5-di-tert-butyl salicylaldehyde(dtbsali)［or 2-hydroxy-1-naphthaldehyde（hnaph）］ as materials. The structures were characterized by IR, HR-ESI-MS， molar conductance and single-crystal X-ray. 1（CCDC：1 429 158） and 2（CCDC：1 429 159）belongs to monoclinic crystal system and triclinic system， respectively． The in vitro anticancer activities of 1 and 2 against A549 and HeGp2 were tested by MTT method. The results showed that 1 and 2 exhibited certain antitumor activities.
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Received: 08 October 2015
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2015, Vol. 23 
