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Synthesis of A Key Intermediate for Dolutegravir and Its Refining by Molecular Distillation |
LIU Wei1, FAN Zhen2, LI Hong-wei2, MA Zhen-zhen2, MAO Long-fei3, JIANG Yu-qin3* |
1. China Pharmaceutical Health Industry Co. LTD., Beijing 100061, China;2. Topfond Pharmaceutical Co. Ltd., Zhumadian 463000, China; 3. School of Chemistry and Chemical Engineering, Henan Engineering Research Center of Chiral Hydroxyl Pharmaceutical, Henan Normal University, Xinxiang 453007, China |
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Received: 23 November 2017
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