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| Synthesis of Novel Maleimide-Pyrazolone-Derived MBH Carbonates by the Morita-Baylis-Hillman Reaction of Pyrazolediones with Maleimides |
ZHENG Jinfeng, TANG Xue, PAN Xiaoli, ZHAN Gu*, HAN Bo* |
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
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Abstract Morita-Baylis-Hillman (MBH) carbonates are important organic synthetic intermediates. Thus, developing new types of MBH carbonates is of great interest. A Morita-Baylis-Hillman (MBH) reaction of pyrazolediones with maleimides has been developed in the presence of DABCO. Twelve novel maleimide-pyrazolone-derived MBH carbonates were obtained in 40%~87% yields. The structures were characterized by 1H NMR, 13C NMR and HR-MS (ESI).
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Received: 01 March 2022
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