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| Synthesis of Novel Glycoconjugates of Genisteins with 1,2,3-Triazoles Moiety |
| YANG Xue-mei, CHEN Zi-lin, JIA Zhen-bin |
| School of Pharmacy, Guangdong Medical College, Dongguan 523808, China |
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Abstract 7-O-propargyl genistein(3) was synthesized by a two-step reaction, using genistein as the starting material. 7-O-［1-(2,3,4,6-tetra-O-acetyl-β-D-glycosidic)-1H-1,2,3-triazole-4-methyl］-genistein(5a~5c) were synthesized by Click reaction of 3 with azido acetyl sugar, using CuI as the catalyst. Glycoconjugates（6a~6c） of genisteins with 1,2,3-triazoles moiety were synthesized by deacetylation of 5. 3, 5 and 6 were novel compounds and the structures were characterized by 1H NMR, 13C NMR and HR-MS.
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Received: 20 November 2014
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2015, Vol. 23 
