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| Synthesis of Novel Pyrrole Derivatives with α,β-Unsaturated Ketones under Ultrasound Irradiation |
| ZHU Yan-ting1, SHAN Yan-qiang2, YAN Kun1, CUI Ke-ke1, LI Min1, WANG Shi-fan1 |
| 1. Department of Pharmaceutical Engineering, School of Ocean, Hainan University, Haikou 570228， China； 2. Qilu Pharmaceutical（Hainan）Co., LTD., Haikou 570314, China |
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Abstract The intermediates, 5-formyl-3-methyl-1H-pyrrole-2,4-dicarboxylic ester（4a~4d）, were obtained by nitrosation, Knorr condensation and oxidization using ethyl acetoacetate and methyl acetoacetate as raw materials. Four novel pyrrole derivatives were synthesized by Aldol condensation of 4a~4d with acetone under ultrasound irradiation. The structures were characterized by IR, 1H NMR and HR-ESI-MS.
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Received: 26 November 2014
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2015, Vol. 23 
