新型含游离羟基鱼藤素衍生物的合成及其抗肿瘤活性

doi:10.15952/j.cnki.cjsc.1005-1511.2015.11.1013

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Abstract Deguelin was prepared by three step reaction from Rotenone. Novel deguelin derivatives containing free hydroxyl groups(3a~3c and 4) were synthesized by boron tribromide demethylation or reduction with sodium cyanoborohydride from deguelin. The structures were characterized by ¹H NMR， ¹³C NMR and LC-MS. The antitumor activities were investigated. The results showed that 12-hydroxyl deguelin(4) showed the best inhibition activities against MCF-7 and H1299 with IC₅₀ of 0.11 μmol·L-¹ and 0.01 μmol·L^-1, respectively, which was better than deguelin.

Received: 27 May 2015

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	Articles by authors
	HE Hai
	JIANG Zhi-hui
	ZHOU Xing-zi
	HE Sheng
	WU Xin-rong

Cite this article:

HE Hai,JIANG Zhi-hui,ZHOU Xing-zi, et al. Synthesis and Antitumor Activities of Novel Free Hydroxyl-containing Deguelin Derivatives[J]. Chinese Journal of Synthetic Chemistry, 2015, 23(11): 1013-1016.

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http://www.hchxcioc.com/EN/10.15952/j.cnki.cjsc.1005-1511.2015.11.1013 OR http://www.hchxcioc.com/EN/Y2015/V23/I11/1013

[1]	. [J]. Chinese Journal of Synthetic Chemistry, 2015, 23(12): 0-0.