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| Synthesis of N-Substituted Benzyl Amides |
| LIU Yue-jin1, WANG Yu-ting1, YU Chun-ying2 |
| 1. College of Pharmaceutical and Biological Engineering， Shenyang University of Chemical Technology， Shenyang 110142, China； 2. Jiangsu Province Haosen Pharmaceutical Co., Ltd．, Lianyungang 224200, China |
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Abstract Six N-benzyl amides were synthesized by amidation reaction of 3-methoxy benzylamine， (S)-α-phenylethylamine， (R)-α-phenylethylamine or benzylamine with pentanoic acid, hexadecanoic acid, palmitic acid, 4-nitrobenzoic acid or m-chlorobenzoic acid, respectively, using p-toluenesulfonic acid as the catalyst in toluene. The yields were 10.7%~22.3%, and N-(3-methoxybenzyl) pentanamide was a new compound. The structures were characterized by 1H NMR, IR and elemental analysis.
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Received: 21 November 2014
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2015, Vol. 23 
