4-Fluoride benzenesulfonamide(2a) and 4-trifluoromethyl benzenesulfonamide(2n) were synthesized by ammonifination from corresponding benzenesulfonyl chloride. A series of substituted phenylisocyanates(4a~4m, 4t, 4I) were obtained by reaction of substituted anilines with triphosgene. Finally, twentyseven novel N-substituted phenyl-4-fluoride(or trifluoromethyl) benzenesulfonylureas were synthesized by condensation of 2 with 4, respectively. The structures were characterized by ¹H NMR， IR and ESI-MS.