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| Synthesis of Glucuronic Acid by Selective Oxidation of Methyl Glucoside with Active MnO2 under Microwave |
| WU Jia-xiong, YUAN Hua, ZHANG Pei, ZHANG Hua-liang, WU Yuan-xin |
| Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemistry Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430073， China |
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Abstract Glucuronic acid was synthesized by selective oxidation with active MnO2 under the microwave radiation and oxidation with H2O2 from methyl glucoside. The structure was confirmed by HPLC and LC-MS. The effects of different oxidative conditions on the yield were studied. The results showed that active MnO2 exhibited good oxidative activity and selectivity under the microwave radiation, and greatly shortened the reaction time. The optimum reaction conditions were as followed: active MnO2 as the oxidant, mass ratio of methyl glucoside and active MnO2 was 1:4, under microwave(400 W), at 80 ℃ for 2 h, the yield was 79%.
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Received: 06 July 2015
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2015, Vol. 23 
