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| Iodine catalyzed Friedel-Crafts Benzylation of 2,2,2-Trifluoro-1-(1H-indol-3-yl)-ethanol with Substituted Anilines |
| HAN Xiao-yu1, XIANG Yan-yan2, JIN Ning-ren2, WANG Yong-jiang1 |
| １. School of Biological and Chemical Engineering/School of Light Industry, Zhejiang University of Science Technology, Hangzhou 310023, China; ２. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China |
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Abstract Eight novel 3-substituted indole derived anilines were firstly synthesized by Friedel-Crafts benzylation of 2,2,2-trifluoro-1-(1H-indol-3-yl)-ethanol with substituted anilines using iodine as the efficient catalyst. The yields were ６５%～９８%. The structures were characterized by 1H NMR， 13C NMRand HR-ESI-MS.
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Received: 18 November 2014
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2015, Vol. 23 
