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| Synthesis and Anti-tumor Activities of Novel Steroidal N,N-dimethylthiosemicarbazone Compounds |
| HUANG Yan-min, ZHENG Jia-hua, ZHAO Dan-dan, QI Bin-bin, YANG Chunhui, SHENG Hai-bing, GAN Chun-fang, CUI Jian-guo |
| College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 53001, China |
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Abstract Four novel N,N-dimethylthiosemicarbazone compounds(1~4) were synthesized by condensation reaction of dehydroepiandrosterone， pregnenolone, estrone, 3,5-dihydroxy-6-formyl-B-norcholestane with N,N-dimethylthiosemicarbazide, respectively, using EtOH(or MeOH) as solvent and HAc as catalyst. The structures were characterized by 1H NMR， 13C NMR, IR and HR-EI-MS. The anti-tumor activities of 1~4 against human hepatoma cells(HepG), nasopharyngeal carcinoma cells(CNE-2) and normal kidney epithelial cells(HEK293T) were investigated by MTT method. The results showed that 1~3 had better antiproliferative activities against HepG and CNE-2.
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Received: 09 September 2015
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2015, Vol. 23 
