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Synthesis and Anticancer Activities of Novel Oxovanadium(IV) Complexes[VO(dtbsal-met)(phen) and VO(naph-met)(phen)] |
CAO Ya-ping, YI Cen-lan, LIU Hong-mei,LI Hai-xia, ZUO Jian-li, YUAN Ze-li |
School of Pharmacy, Zunyi Medical University, Zunyi 563003, China |
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Abstract Two novel oxovanadium(IV) complexes, VO(dtbsal-met)(phen)(1) and VO(naph-met)(phen)(2), were synthesized by aldimine condensation reaction reaction, using L-methionine(meth), 1,10-phenanthroline(phen), 3,5-di-tert-butyl salicylaldehyde(dtbsali)[or 2-hydroxy-1-naphthaldehyde(hnaph)] as materials. The structures were characterized by IR, HR-ESI-MS, molar conductance and single-crystal X-ray. 1(CCDC:1 429 158) and 2(CCDC:1 429 159)belongs to monoclinic crystal system and triclinic system, respectively. The in vitro anticancer activities of 1 and 2 against A549 and HeGp2 were tested by MTT method. The results showed that 1 and 2 exhibited certain antitumor activities.
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Received: 08 October 2015
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