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| Synthesis of Two Novel Diacetylene Derivatives |
| CHEN Bei-hua1a, ZHANG Zhen1a， ZHANG Deng-qing1a，LI Xian-ying1b， XIANG Yun-jie1a, JIN Wu-song1a |
| a. College of Chemistry, Chemical Engineering and Biotechnology; b. School of Environmental Science and Engineering, 1. Donghua University, Shanghai 201620, China |
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Abstract A novel diacetylene derivative（1） was synthesized by improved Glasercoupling reaction(CuI as catalyst and Et3N as solvent) of 3-ethynyl-5-(3-methyl-3-hydroxyl)-butynyl-1-(3-dodecyloxy)-2-{［(dodecyloxy)methyl］propoxy｝benzene（6）, which was obtained by selective Sonogashira reaction, Sonogashiracoupling reaction and deprotection from 3,5-dibromo-1-｛3-(dodecyloxy)-2-［(dodecyloxyyl)methyl］propoxy｝benzene and 2-methyl-3-butyn-2-ol． A novel diacetylene derivative（2） was synthesized by Sonogashira reaction, THP deprotection reaction and improved Glasercoupling reaction from 6 and 2,2′-［(2,5-diiodo-1,4-phenylene)bis(oxy)］bis(tetrahydro-2H-pyran)． Structures of intermediate， 1 and 2 were characterized by 1H NMR， 13C NMR and MALDI-TOF-MS.
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Received: 26 December 2014
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2015, Vol. 23 
