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| Synthesis of Novel Xanthene-dione Derivatives Containing 2-Quinolone Moiety |
| WANG Xuan1, ZHANG Zhen-ming1,2, WANG Run-nan2, ZHANG Dan-dan2, LI Shu-an2 |
| 1. School of Chemical Technology, China University of Mining and Technology, Xuzhou 221116, China; 2. School of Chemical Technology, Huaihai Institute of Technology, Lianyungang 222005, China |
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Abstract Five novel xanthene-dione derivatives containing 2-quinolone moiety were synthesized in yields of 78%~90% by reaction of substituted 2-chloroquinoline-3-carbaldehyde with 5,5-dimethyl-1,3-cyclohexanedione， using acetic acid as catalyst and DMF as solvent at 80 ℃~100 ℃ for 2.5 h~4．0 h.The structures were characterized by 1H NMR， IR， HR-ESI-MS and elemental analysis. X-ray single crystal diffractometer of 3,3,6,6-tetramethyl-9-{3-［7-methylquinolyl-2(1H)-one］}-2,4,5,7,9,10-hexahydro-xantene-1,8(2H,5H)-dione(3b) tests indicated that 3b（CCDC： 971 833） belongs to monoclinic crystal system, space group C12/C1 with a=1.411 90（16）nm， b=2.231 4（2）nm， c=1.618 28（18）nm， β=106.904°， V=4.878 1（9） nm3， Dc=1.175 g·cm-3, Z=1， R1=0.044 4， wR2=0.074 6.
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Received: 24 July 2015
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2015, Vol. 23 
