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| Synthesis and Anti-inflammatory Activities of Oxazolone Compounds |
| SUN Yin-xing1, XU Guang-lin2, HOU Bing-bo1, AO Gui-zhen1 |
| 1. Faculty of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China; 2. New Drug Research Center of Faculty of Life Science, Nanjing Normal University, Nanjing 210046, China |
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Abstract Eight oxazolone compounds(3a~3h) were synthesized by Erlenmeyer cyclization of hippuric acid with substituted benzaldehyde. The structures were confirmed by 1H NMR, FT-IR and HR-MS. The results of anti-inflammation by xyleneinduced mice ear edema suggested that 3f［4-（3,5-dimethoxy-benzylidene)-2-phenyl-4H-5-oxazolone］ exhibited better anti-inflammatory activity(50.3%) than aspirin(41.5%).
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Received: 19 March 2015
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2015, Vol. 23 
