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| Synthesis and Antidepressant Activities of 4-Hydroxybenzal-dehyde Schiff Base Derivatives with Phosphate Ester Group |
| 刘进兵， 吴凤艳 |
| Department of Biology and Chemical Engineering, Shaoyang University, Shaoyang 422000, China |
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Abstract Four 4-hydroxybenzaldehyde Schiff base derivatives(4a~4d) with phosphate ester group were synthesized by condensation reaction of primary amine with 2-(4-formylphenoxy)ethyl dimethyl phosphate（2）, which was prepared by etherification and esterification from 4-hydroxybenzaldehyde. The structures were confirmed by 1H NMR, 13C NMR, IR and ESI-MS. Their antidepressant activities were investigated by emergency model. The results showed that 2 and 2-｛4-［(methoxyimino)methyl］phenoxy｝ethyl dimethyl phosphate（4d） had certain antidepressant activities in vivo. And 2 showed the better antidepressant activity than imipramine.
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Received: 17 March 2015
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